The victim, a male resident, died at the hospital and has not yet been identified, they said.
U.S. President Donald Trump, who has an office and a private residence in the midtown Manhattan structure, was not in the building at the time.
“Fire at Trump Tower is out. Very confined (well built building). Firemen (and women) did a great job. THANK YOU!” Trump tweeted. Fire officials have not yet released a suspected cause of the blaze, adding no member of the Trump family was in the building at the time.
“This was a very difficult fire. As you can imagine, the apartment is quite large, we are 50 stories up. The rest of the building had a considerable amount of smoke,” Fire Commissioner Daniel Nigro said on Twitter.
About 200 fire personnel responded to the incident that the department said was a four-alarm fire.
Video on social media showed flames outside of a few windows and black smoke billowing up from the high-rise.
In January, three people were injured in an early-morning fire at the top of Trump Tower. One firefighter was hospitalized while two people received minor injuries that were treated at the scene, the New York Fire Department said.
In addition to the president’s 66th-floor penthouse, Trump Tower houses the headquarters of the Trump Organization as well as other residences, offices and stores.